Glyzempic Clinical Studies

Clinical Study 1 – Prediabetes reversal & glycemic control over 12 weeks (Eriomin®)

Eriomin® (citrus flavonoids) for prediabetes. (Ribeiro CB et al., Phytotherapy Research, 2019)  

Design: Double-blind, randomized, placebo-controlled, parallel groups; intervention lasted 12 weeks.
Participants: 103 Prediabetic adults, mean age 49 ± 10 years. 
Intervention: Daily Eriomin® capsule after dinner for 12 weeks — 200 mg, 400 mg, or 800 mg vs placebo.

What is HbA1c: A blood marker reflecting average blood glucose over ~2–3 months. Lower HbA1c = better long-term glucose control. (The study tracked HbA1c alongside fasting glucose and glucose tolerance.)

Key findings (Week 12 vs baseline):

• Fasting blood glucose: reduced by 4–6% across Eriomin doses.  
• HbA1c: reduced by 2%.  
• Glucose tolerance (2-hr OGTT): reduced by 6–7%.  
• Insulin resistance (HOMA-IR): reduced by ~6–8%.  
• Inflammation & metabolic markers (average): hsCRP −12%, IL-6 −13%, TNFα −11%, GLP-1 +15%, adiponectin +19%.

What this means: Over 12 weeks, Eriomin® improved multiple markers linked to prediabetes. It lowers fasting glucose, providing better glucose tolerance, HbA1c improvement, lower insulin resistance and inflammation. About 1 in 4 participants shifted back to normal blood glucose during the study period.

Clinical Study 2 – Post-meal glucose control & GLP-1 maintenance on metformin (12 weeks)

Citrus flavonoids (Eriomin®) as an add-on to metformin in prediabetes. (Cesar T. et al., Frontiers in Nutrition, 2025)

Design: Double-blind, randomized, placebo-controlled crossover trial (two 12-week phases with a washout). All participants stayed on metformin 1,000 mg/day.  

Participants: 71 adults with prediabetes were randomized 

Interventions: Eriomin® 250 mg/day + metformin vs placebo + metformin, taken once daily with the evening meal.

Key findings (Week 12 vs baseline):

• Better after-meal blood sugar: 2-hour OGTT down 5% (placebo went up 7%).
• Active GLP-1: Maintained (placebo dropped 15%). 
• Inflammation: TNF-α down 12%.
• Blood pressure: Systolic BP down 4 mmHg. 

What this means: If you’re already on metformin, adding citrus flavonoids helped support steadier after-meal blood sugar and maintained GLP-1 signalling, alongside improvements in inflammation and antioxidant status.  

Note: This is supportive nutrition—not a replacement for medication. The study reports the add-on was well tolerated with no major adverse events reported.